Fig. 4From: Recurrence with pagetoid spread arising 17 years after surgery for intramucosal rectal cancer: a case reportThe tumor lesion occupied the perianal region and rectum, with internal anal sphincter invasion (a). Many Paget cells (arrow head) were observed in the squamous epithelium (b). There were moderately to poorly differentiated adenocarcinoma cells in the submucosal layer (c)Back to article page