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Table 1 The characteristics of primary ectopic breast carcinoma of the vulva

From: Primary ectopic breast cancer of the vulva, treated with local excision of the vulva and sentinel lymph node biopsy: a case report

Ref. Year Age Size (cm) operation Adjuvant therapy Histology ER PR Her2 LN Status Follow-up (months)
Greene [12] 1935 59 20 None None Adenocarcinoma * * * * Dead 1
Hendrix [13] 1956 58 3 Vulvectomy None Adenocarcinoma * * * * Dead 4
Guerry [14] 1976 62 1.5 Partial None Ductal carcinoma * * * * Dead 24
Cho [15] 1985 70 4 Hemi-vulvectomy + LND Tamoxifen Adenocarcinoma (+) (+) * 2/9 DF 24
Simon [16] 1988 60 2 Vulvectomy + LND1 CT + tamoxifen Adenocarcinoma (+) (+) * 3/11 Dead 27
Rose [17] 1990 68 3.5 Vulvectomy RT + tamoxifen Ductal carcinoma (+) (−) * 1/15 * *
Bonito [18] 1992 46 1.5 Vulvectomy + LND None * * * * 11/13 DF 4
Bailey [19] 1993 65 3 Vulvectomy + LND Tamoxifen Ductal carcinoma (+) (+) * 2/20 DF 12
Levin [20] 1994 62 2.5 Partial + LND Tamoxifen Adenocarcinoma (+) (−) (+) 4/11 DF 24
Kennedy [21] 1997 71 5 Vulvectomy + LND CT + RT * (−) (−) * 9/9 DF 15
Irvin [22] 1998 64 3 Partial + LND CT + RT-F tamoxifen Adenocarcinoma (+) (+) * 1/14 DF 4
Gorisek [23] 2000 81 3 Partial Tamoxifen Adenocarcinoma (+) (+) *   DF 19
Neumann [24] 2000 60 3 Hemi-vulvectomy + LND CT + RT + tamoxifen ILC (+) (+) * 21/21 DF 20
Piura [25] 2002 69 3 Vulvectomy + LND CT + tamoxifen Adenocarcinoma (+) (+) * 7/15 DF 14
Chung [26] 2002 47 2 Vulvectomy None Mucinous (+) (+) (−) * DF 36
Yin [27] 2003 84 5 Partial + LND None Mucinous (+) (+) (−) 1/11 DF 9
Lopes [28] 2006 44 2 Partial + LND CT + tamoxifen Mucinous (+) * (−) 2/13 * *
Fracchioli [29] 2006 57 1 Vulvectomy + LND CT + tamoxifen Adenocarcinoma (−) * * 7/7 Rec 36
North [4] 2006 49 1.5 Partial + LND CT + tamoxifen Ductal carcinoma (+) (+) (−) 5/7 * *
Martinez [10] 2007 49 3.5 Partial + SLNB—LND Tamoxifen Ductal carcinoma (+) (+) * 0/14 * *
Naseer [30] 2011 57 1.5 Partial + LND CT + aromatase Ductal carcinoma (+) (+) (−) 3/13 * *
Diniz [2] 2012 82 2 Partial RT + letrozole IDC (+) (+) * * DF 48
McMaster [31] 2013 60 3 Partial RT Ductal carcinoma (+) * * * * *
Bogani [9] 2013 71 4 Vulvectomy + SLNB—LND CT + tamoxifen Ductal carcinoma (+) (+) * 1/8 DF 24
Lamb [5] 2013 59 1 Partial + LND Tamoxifen Adenocarcinoma (+) (+) (−) * * *
James [7] 2015 62 1.3 Partial CT + RT IDC (+) (+) (−) * Rec 13
Present case 2016 72 1.5 Partial + SLNB Aromatase IDC (+) (+) (−) 0/1 DF 6
  1. LND (inguinal)lymph node dissection, LND1 (inguinal and pelvic) LND, SLNB sentinel lymph node biopsy, CT chemotherapy, RT radiotherapy, ILC invasive lobular carcinoma, IDC invasive ductal carcinoma, Dead death of disease, DF disease-free, Rec recurrence, * unknown