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Fig. 3 | Surgical Case Reports

Fig. 3

From: Combined small cell lung carcinoma and giant cell carcinoma: a case report

Fig. 3

Immunohistochemical staining of the tumor. a Representative image of the tumor comprised of small cell component and giant cell component (hematoxylin and eosin stain). b Both the small cell and giant cell components were TTF-1-positive and p40-negative. c Both the small cell and giant cell components exhibited neuroendocrine differentiation (positive for synaptophysin and CD56 but negative for chromogranin A). d, e While the small cell component was E-cadherin-positive and vimentin-negative, the giant cell component was E-cadherin-negative and vimentin-positive, indicating EMT. HE hematoxylin and eosin, G giant cell component, S small cell component

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