Fig. 4

Macroscopic and histopathologic findings of the surgical specimen. Grossly, most of the tumorous tissue is replaced by hemorrhage (a). Hematoxylin–eosin staining shows the absence of atypical cells and normal portal vein area, but there are hepatocyte proliferation and expanded blood vessels (b, ×40). Immunohistochemical analyses (c–e) show inactivation of β-catenin and no attenuation of the LFABP (c, β-catenin, ×40, and d, LFABP, ×40). Glutamine synthetase in the tumor region presents as the so-called geographic map-like pattern (e, arrows ×40). LFABP, liver fatty acid-binding protein