Table 1 Summary of two case of nilotinib resistant GIST
Case 1 | Case 2 | |
|---|---|---|
Age (year) | 70 | 66 |
Gender | Female | Female |
Primary lesion | Small intestine | Small intestine |
Modified-Fletcter’s classification | High risk | High risk |
Primary KIT mutation | Exon11 Lys558 to Asn&Pro | Exon11 Del-5a.a.(557–561) |
Adjuvant therapy | None | Imatinib (1 year) |
Recurrence site | Peritoneal dessemination | Peritoneal dessemination |
Duration from nilotinib administration to resistance (month) | 56 | 53 |
Reason of resection for metastasis | Ileus for metastasis | Increase of metastasis |
Secondary mutation | None | Exon13 Asn655Thr |