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Surgical Case Reports

Table 1 Outcome of concomitant treatment plus R1 surgery in patients with ECC

From: A long survivor with local relapse of hilar cholangiocarcinoma after R1 surgery treated with chemoradiotherapy: a case report and literature review

Year

Total number

Patient and treatment for residual cancer cells

Number of R1 patients

Locoregional failure (%)

P value

Distant failure (%)

P value

Ref

2006

81

Surgery + RT (45–59 Gy) + CTx (5FUa or GEM)

R0:12, R1:16

11 (39.3)

–

7 (25.0)

–

9

2012

25

Surgery + RT (45–50Gy) + CTx (GEM)

8

1 (12.5)

–

4 (50.0)

–

8

2013

25

Surgery → local relapse → EBRT (48Gy) + CTx (CDDP or 5FUa)

6

2 (33.3)

–

3 (50.0)

–

7

2015

336

Surgery alone

22

13 (59.1)

0.003

16 (72.7)

0.007

6

  

Surgery + CTx (5FUa + CDDP or GEM)

12

7 (58.3)

 

3 (25.0)

  
  

Surgery + RT (40–50 Gy)

13

2 (15.4)

 

6 (46.2)

  
  

Surgery + CRT (5FUa or GEM + RT)

20

3 (15.0)

 

5 (25.0)

  
  1. RT radiation, CTx chemotherapy, GEM gemzal, EBRT external beam radiation therapy, CDDP cisplatin, CRT chemoradiation
  2. a5FU: 5-Fluorouracil-based chemotherapy such as capecitabine, TS1, and infusion of 5FU
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