Metachronous cholangiocarcinoma 13 years post resection of choledochal cyst—is long-term follow-up useful?: a case study and review of the literature

Surgical Case Reports

Table 1 Publications of cholangiocarcinoma occurring after resection of choledochal cyst reported in the literature

Study	No. of patients with CC	Median age (years)	Type of cyst	Median duration to development of CC (years)	Median follow-up (months)	Site of cancer	Treatment	Median survival after development of CC (months)
Case reports 1967–2014 [4, 7–21]	18	39 (18–62)	14 type 4a, 2 type 1, 2 ND	18 (2–34)	48 (24–120 from 4 studies)12 studies with no follow-up done	9 intrahepatic duct, 7 hilar, 1 intrapancreatic, 1 ND	9 resected, 4 unresectable, 5 death before surgery	Resected, 10 (6-30), Unresectable 3 (2-4)
Ohashi et al. 2013 [11]	4	41 (27–65)	2 type 1, 2 type 4a	19 (13–32)	181 (7–484)	2 intrahepatic duct, 1 hilar, 1 intrapancreatic duct	All resected	15 (9–43)
Rossi et al. 1986 [16]	6	41 (22–70)	1	4 (1–18)	39	4 extra-hepatic bile duct, 2 intrahepatic bile duct	3 resected, 3 unresectable	4 (1–6)
Scudamore et al. 1994 [22]	1	ND	4 a	2	24	Intrahepatic	Resected	24
Joseph et al. 1996 [23]	1	29	4 a	3	ND^a	Intrahepatic	Unresectable	36
Shah et al. 2009 [24]	1	42	4 a	2	28	Extra-hepatic bile duct	Unresectable	2