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Table 1 Baseline characteristics of the four study patients

From: Spontaneous clearance of hepatitis C virus after liver transplantation: a report of four cases

  Case 1 Case 2 Case 3 Case 4
Age (years) 66 61 55 55
Sex Male Male Male Male
MELD score (points) 21.4 11 33 8
Child-Pugh (score) B (9) B (9) C (13) B (7)
Preoperative HCV-RNA (log IU/ml) 5.3 2.3 2.1 5.5
HCV treatment status PEG-IFN → nonresponder (8 years in advance of LT) IFN → terminated due to psychological side effect (21 years in advance of LT) IFN → failure (9 years in advance of LT) IFN → nonresponder (8 years advance of LT)
Genotype 1b 2 1b 1b
Rejection episodes None (RAI 2) Yes (RAI 3) None (RAI 1) Yes (RAI 2)
ABO blood type Incompatible Identical Identical Identical
Immunosuppression Rituximab (preoperatively) MMF. FK506, MP MMF, FK506, MP, PSL MMF, FK506, MP, PSL MMF, FK506, MP, PSL
Time to HCV clearance after LT (days) 152 141 177 14
Re-emergence of HCV-RNA None None None Yes (day 85)
Perioperative morbidity Sepsis Sepsis   ACR, steroid pulse
Follow-up periods (years) 5 5 9 1
  1. MELD Model for End-Stage Liver Disease, LT liver transplantation, MMF mycophenolate mofetil, FK506 tacrolimus, MP methylprednisolone, PSL prednisolone, ACR acute cellular rejection