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Table 1 Three major histopathological features and international pathological consensus minimal criteria for diagnosing IgG4-related disease in a new organ/site

From: Immunoglobulin G4-related sclerosing cholecystitis presenting as gallbladder cancer: a case report

The three major histopathological features associated with IgG4-related disease

Dense lymphoplasmacytic infiltrate

Fibrosis, arranged at least focally in a storiform pattern

Obliterative phlebitis

Other histopathological features associated with IgG4-related disease are as follows:

Phlebitis without obliteration of the lumen

Eosinophilia

Minimal criteria for IgG4-related disease in a new organ/site

Characteristic histopathological findings with an elevated IgG4 plasma cells and IgG4/IgG ratio

High serum IgG4 concentrations

Effective response to glucocorticoid therapy

Reports of other organ involvement that is consistent with IgG4-related disease