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Table 1 Reported cases of primary pancreatic leiomyosarcoma in the English literature

From: Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature

Case Author Year Age, year/sex Site/size, cm Distant metastasis Treatment Grade IHC Outcome/follow up, months
1 Ross [5] 1951 80/M Whole pancreas Widespread Autopsy case High n.a. DOD
2 Berman and Levene [6] 1956 47/M Head/5.5 No PD n.a. n.a. ANED/12
3 Feinberg et al [7] 1957 14/M Head/11.0 No PD Low n.a. n.a.
4–8 Baylor and Berg (n = 5) [4] 1973 51 (median)/3M, 2F Body-tail/n.a. 1 localised, 1 locally advanced, 3 disseminated n.a. n.a. n.a. ANED (n = 1)/1; DOD (n = 3)/14 (median)
9 Ishikawa et al [8] 1981 44/M Head/8.0 No PD/CT Low n.a. DOD/48
10 Lakhoo and Mannell [9] 1991 68/M Body/17.0 No DP, gastric resection, transverse colectomy Low n.a. ANED/24
11 de Alava et al [10] 1993 71/M Body/3.6 No DP n.a. (+) desmin, smooth muscle actin, vimentin; (−) AE1/AE3, CAM5.2 n.a.
12 Peskova and Fried [11] 1994 68/F Head/15.0 No PD Low n.a. ANED/36
13 Sato et al [12] 1994 53/F Body/25.0 No DP n.a. (+) desmin, smooth muscle actin; (−) S-100, EMA n.a.
14 Ishii et al [13] 1994 66/M Tail/4.5 Liver Non resectable/CT n.a. (+) desmin, smooth muscle actin DOD/33
15 Aranha et al [14] 1995 46/F Body/3.0 No DP/CT High (+) desmin; (−) S-100, cytokeratin, HMB-45 DOD/9
16 Owen et al [15] 1997 40/M Head/7.0 No PD n.a. (+) desmin, smooth muscle actin ANED/120
17 Shimizu et al [16] 1997 49/F Head/15.0 Lung Non resectable/CT n.a. (+) desmin, smooth muscle actin; (−) S-100 DOD/3
18 Chawla et al [17] 1998 45/F Head/9.2 Lung Non resectable/CT Low (+) smooth muscle actin AWD/19
19 Paciorek and Ross [18] 1998 63/F Body/2.0 Mesentery, single DP n.a. n.a. ANED/n.a.
20 Zalatnai et al [19] 1998 57/M Head/6.0 Liver Non resectable 3 (+) smooth muscle actin, SMA; (−) S-100, desmin DOD/7
21 Ferlan-Marolt et al [20] 2000 57/F Body-tail/12.0 No DP 2 (+) SMA; (−) desmin DOC/p.o. period
22 Machado et al [21] 2000 52/M Head/7.5 No PD Low (+) SMA; (−) S-100 ANED/24
23 Deveaux et al [22] 2001 44/F Head/5.0 No PD 1 (+focal) smooth muscle actin; (−) S-100, keratin ANED/48
24 Nesi et al [23] 2001 76/M Tail/8.0 No DP High (+) smooth muscle actin, SMA; (−) desmin, CD34, cytokeratin, S-100 DOD/12
25 Aihara et al [24] 2002 25/F Body/3.5 No Local excision n.a. (+) desmin, smooth muscle actin; (−) S-100 ANED/42
26 Komoda et al [25] 2002 52/F Head/1.5 No PD Low (+) desmin, smooth muscle actin; (−) S-100, CD34, KIT ANED/12
27 Maarouf et al [26] 2007 40/F Tail/5.0 No DP Low (+) desmin, smooth muscle actin, H-caldesmon; (−) CD34 ANED/240
28 Muhammad et al [27] 2008 73/M Body/10.0 Liver Non resectable/CT Low to intermediate (+) desmin, smooth muscle actin; (−) S-100, CD34, cytokeratin AE1/AE3, HMB45 DOD/3
29-37 Zhang H et al [28] (n = 9) 2010 63 (median)/5M, 4F Head (n = 7); Tail (n = 2)/8.0 (median) Liver (n = 4) PD (n = 4); Palliative/biopsy (n = 5) Grades 4 (n = 1), 3 (n = 5), 2 (n = 3) (+) smooth muscle actin, desmin; (−) KIT DOD (n = 5), DOC/Unknown (n = 4)/13 (median)
38 Riddle et al [29] 2010 83/F Tail/8.2 No DP 2 (+) smooth muscle actin, desmin, vimentin; (−) c-kit, CD34, S-100, pan-cytokeratin ANED/8
39 Zhang et al [30] 2011 56/F Body-tail/13.0 No DP 2 (+) desmin, smooth muscle actin, H-caldesmon, vimentin; (−) cytokeratin, CD34, S-100, CD117 ANED/14
40 Hur et al [31] 2011 70/F Head/5.0 No PD 2 (+) actin, vimentin, desmin; (−) cytokeratin, S-100, CD34, CD117 DOD/22
41 Izumi et al [32] 2011 41/F Body/4.5 No DP n.a. (+) smooth muscle actin, desmin, vimentin ANED/14
42 Vanderpuye et al [33] 2011 59/F Tail/24.0 Liver, transverse colon DP/ CT + RT n.a. n.a. AWD/24
43 Moletta et al [34] 2012 54/F Body and tail/13.0 Liver DP, left hepatectomy/CT 3 (+) smooth muscle actin, desmin; (−) cytokeratin, CD34, S-100, CD117 AWD/37
44 Kim et al [3] 2014 51/F Tail/5.5 No DP/RT 2 (+) desmin, SMA; (−) CD117, HMB45, CD34 ANED/27
45 Present case 2014 60/F Head/10.0 No Local excision 2 (+) smooth muscle actin, desmin, caldesmon;(−) S-100, CD117 ANED/19
  1. ANED alive and no evidence of disease, AWD alive with disease, cm centimetres, CT chemotherapy, DOC died of other cause, DOD died of disease, DP distal pancreatectomy, IHC immunohistochemistry, n number of cases, n.a. not available, PD pancreatico-duodenectomy, p.o. postoperative, RT radiotherapy