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Table 2 Immunohistochemical features of primitive neuroectodermal tumors of the pancreas

From: A peripheral primitive neuroectodermal tumor originating from the pancreas: a case report and review of the literature

Reference MIC-2 (CD99/O13/12E7) NSE AE1/AE3 VIM SYN CHR Cytogenetic analysis Chromosomal translocation
Danner [9] + + + NP RT-PCR EWS exon 7 to FLI1 exon6
Luttges [8] + + + + NA NA
  + + + NA NA
Bulchmann [10] + + NP FISH EWSR1
O’Sullivan [11] + NP + NP NP RT-PCR EWS exon 7 to FLI1 exon5
Gemechu [12] NP NP NP NP + + NA NA
Movahedi [2] + + + NP RT-PCR EWS-FLI1
  + + NP NA NA
  + + + NP + + RT-PCR EWS-FLI1
  + + NP NP RT-PCRa
  + + NP NA NA
  + + + NP + NP RT-PCR EWS-FLI1
Takeuchi [13] + + + NP NP NP RT-PCR EWS-FLI1
Perek [14] + NP NP + + a
Welsch [15] + + + + + NP FISH EWSR1
Schutte [16] + NP + + + NA NA
Wakao [17] + NP NP NP NP NP RT-PCR EWS-FLI1
Doi [18] + + + NP NP FISH EWSR1
Menon [19] + NA NA NA NA NP NA NA
Jing [20] NA NA NA NA NA NP NA NA
Maxwell [21] + NP + + NP RT-PCR EWS-ERG
Mao [22] + + NP RT-PCR EWS-FLI1
Reilly [23] + + + RT-PCR EWS-FLI1
Dias [24] + NP NP NP FISH EWSR1
Present case + + + + FISH EWSR1
  1. − absent, + present, AE1/AE3 cytokeratin AE1/AE3, CHR chromogranin A, EWSR1 Ewing sarcoma breakpoint region 1 gene one on 22q12, FISH fluorescence in situ hybridization, NA not available, NP not performed, NSE neuron-specific enolase, RT-PCR reverse transcript polymerase chain reaction, SYN synaptophysin, VIM vimentin
  2. aRNA exhaustion from a paraffin block was impossible