Chemoradiation therapy with S-1 for primary squamous cell carcinoma of the rectum: report of three cases

Surgical Case Reports

Table 1 Patients treated with chemoradiation therapy with S-1

Number	Gender	Age	Location	Size (mm)	cStage	RT (gray/fraction)	CT	Adverse events (CTCAE v4.0)	SCC Ag before CRT	SCC Ag after CRT	Operation	Response	Prognosis
1	F	54	Rb	21.5	III B	59.4/33	S-1 alone	None	9.3	0.9	-	CR	Disease-free for 3 years 8 months
2	F	84	Rb	42.6	II A	59.4/33	S-1 alone	None	6.8	0.9	-	CR	Disease-free for 2 years 1 month
3	F	62	Rb-a	44.4	III C	45/25	S-1 alone	Hemorrhage (G-3)	54.3	1.2	PPE	pCR	Bone and liver metastasis at 1 year 2 months
3	F	62	Rb	125	III C	45/25	S-1 alone	Hemorrhage (G-3)	54.3	1.2	PPE	pCR	Bone and liver metastasis at 1 year 2 months

RT, radiation therapy; CT, chemotherapy; CTCAE, common terminology criteria for adverse events; SCC Ag, squamous cell carcinoma antigen; CRT, chemoradiation therapy; Ra, rectum above the peritoneal reflection; Rb, rectum below the peritoneal reflection; CR, complete response; PPE, posterior pelvic exenteration; pCR, pathological complete response.