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Table 2 Immunohistochemical features of primitive neuroectodermal tumors of the pancreas

From: A peripheral primitive neuroectodermal tumor originating from the pancreas: a case report and review of the literature

Reference

MIC-2 (CD99/O13/12E7)

NSE

AE1/AE3

VIM

SYN

CHR

Cytogenetic analysis

Chromosomal translocation

Danner [9]

+

+

+

NP

RT-PCR

EWS exon 7 to FLI1 exon6

Luttges [8]

+

+

+

+

NA

NA

 

+

+

+

NA

NA

Bulchmann [10]

+

+

NP

FISH

EWSR1

O’Sullivan [11]

+

NP

+

NP

NP

RT-PCR

EWS exon 7 to FLI1 exon5

Gemechu [12]

NP

NP

NP

NP

+

+

NA

NA

Movahedi [2]

+

+

+

NP

RT-PCR

EWS-FLI1

 

+

+

NP

NA

NA

 

+

+

+

NP

+

+

RT-PCR

EWS-FLI1

 

+

+

NP

NP

RT-PCRa

 

+

+

NP

NA

NA

 

+

+

+

NP

+

NP

RT-PCR

EWS-FLI1

Takeuchi [13]

+

+

+

NP

NP

NP

RT-PCR

EWS-FLI1

Perek [14]

+

NP

NP

+

+

a

Welsch [15]

+

+

+

+

+

NP

FISH

EWSR1

Schutte [16]

+

NP

+

+

+

NA

NA

Wakao [17]

+

NP

NP

NP

NP

NP

RT-PCR

EWS-FLI1

Doi [18]

+

+

+

NP

NP

FISH

EWSR1

Menon [19]

+

NA

NA

NA

NA

NP

NA

NA

Jing [20]

NA

NA

NA

NA

NA

NP

NA

NA

Maxwell [21]

+

NP

+

+

NP

RT-PCR

EWS-ERG

Mao [22]

+

+

NP

RT-PCR

EWS-FLI1

Reilly [23]

+

+

+

RT-PCR

EWS-FLI1

Dias [24]

+

NP

NP

NP

FISH

EWSR1

Present case

+

+

+

+

FISH

EWSR1

  1. − absent, + present, AE1/AE3 cytokeratin AE1/AE3, CHR chromogranin A, EWSR1 Ewing sarcoma breakpoint region 1 gene one on 22q12, FISH fluorescence in situ hybridization, NA not available, NP not performed, NSE neuron-specific enolase, RT-PCR reverse transcript polymerase chain reaction, SYN synaptophysin, VIM vimentin
  2. aRNA exhaustion from a paraffin block was impossible