Fig. 4From: Total colectomy for multiple metachronous colon cancers in a patient with Lynch syndrome a Detailed microscopic view. The tumor displays heterogeneity of poorly differentiated adenocarcinoma (arrowhead) and well-differentiated adenocarcinoma (arrow). b The lesion consists of mucinous adenocarcinoma. c Immunostaining for the mismatch repair protein MLH1 clearly showed positive staining in the cancerous tissue (arrow) and non-cancerous tissue. d Immunostaining for the mismatch repair protein MSH2 showed positive staining in the non-cancerous tissue (arrowhead), with no staining in the cancerous tissue (arrow)Back to article page